Remapping
neurodegenerative disease
with human data
/Crownlands develops precision medicines for neurodegenerative and CNS diseases with data and scale.
Breakthroughs begin with accurate insight into brain disease.
Crownlands has the fastest-growing human neuron dataset, which we use to understand the root causes of brain disease and reveal treatable biology. Our approach guides transformative medicines from the preclinical bench to doctors’ and patients’ hands.
The brain is the inner frontier
Gateway
Human neurons.
Human progress.
Crownlands Gateway sequences human olfactory neurons one synapse away from the brain to make previously inaccessible human data available at unprecedented scale.
Uncovering the root causes and subtypes of neurodegeneration requires data from people, not proxies. Gateway allows for the collection of real patient neurons in 10 minutes with minimal discomfort.
Gateway is already the fastest-growing neuron biobank.
Discovery Platform
With frontier models of the human brain, Crownlands identifies biology that drives rather than correlates with disease.
Each new subgroup identification enables a precision clinical trial, and each target or biology discovery opens a door to new classes of disease-modifying medicine. Crownlands is a scaled discovery engine.
Biomarker Platform
Clinically accessible neuron data means previously unavailable biomarkers can guide recruitment, track drug effect, and de-risk clinical milestones.
Gateway offers a preferable substrate for many pharmacodynamic readouts and patient stratification.
Accessible human neurons offer insight on hard-to-find factors such as rare transcripts, compartment localization, splicing, and neuron-only pathways. Gateway integrates smoothly into any trial and all sites. We support clinical trials with exploratory and pivotal measures.
At Crownlands, we believe that the most scalable data types harnessed by incredible teams will meet the mission of curing neurodegeneration.
We're looking for exceptional people to Join the mission.
